Endocrine Abstracts

Renal cell carcinoma metastases to adrenal glands are indicative of a generalized tumor process, but in cases of solitary metastases, a radical surgical treatment of these patients is possible.The object of the present study was an estimation of the remote outcome of surgical treatment of 18 patients with solitary renal cell carcinoma metastases to adrenal glands operated on in our clinic over the period from 1999 to 2008. Among them, there were 6 men an...

From 1987 to 2008, 226 patients were operated on for primary hyperparathyroidism (pHPT). In 17 (men and women, aged 21–71 years) of them, parathyroid carcinoma (PC) was verified by histologic analysis. Mixed pHPT form was noted in 12 patients, visceropathic one – in 4, and asymptomatic – in 1. Hypercalcemia was revealed in 14 of 17 patients, and elevation of parathyroid hormone (PTH) level (426–1160 pg/ml) – in 12. In 5 patients operated on before 1990...

The aim of the study was investigating of microvessels density (MD) and expression of vascular endothelial growth factor (VEGF) in adrenocortical tumors.Under investigation there were 23 adrenocortical tumors: adenomas – 13, ‘border’ tumors – 4, and carcinomas – 6. Immunohistochemical studied were carried out using monoclonal antibodies to both VEGF and endothelial marker CD34 (Dako). VEGF expression was estimated as a weak one (...

Adrenocortical carcinoma is a rare tumor characterized aggressive growth and poor prognosis. This tumor requires the complex way of treatment, where basic method is surgery.The aim of this study was to evaluate the long-term outcome and role of surgery in patients with adrenocortical carcinoma.Methods: From 1998 to 2007, 44 patients were operated for adrenocortical carcinoma (14 cortisol-secreting tumors, 1 virilizing tumor and 29 ...

The numerous growth factors and cytokines take part in mechanisms of tumor growth and metastasing.The aim of this study was determination of sFas, IL-6 and VEGF serum levels in 19 patients with adrenal cortical carcinoma (11 women and 8 men aged 21–72 years). The control group comprised 40 practically healthy donors (22 women and 18 men aged 19–70 years). sFas, IL-6 and VEGF before adrenalectomy and in the control were measured by ELISA. Mean I...

Primary bilateral adrenal lymphoma is extremely rare. We report a case of bilateral adrenal lymphoma developing in a 61-year-old woman. The patient presented with weakness, fever, anorexia, nausea, and weight loss. Her vital signs were as follows: body temperature 37.2 °C, pulse rate 98 beats per minute, and blood pressure 125/70 mmHg. Examination of head and neck was unremarkable. Lymphadenopathy and skin lesion weren’t found. The chest X-ray was normal, withou...